Surprise!!! This is not one of those “One-Shot” downs the thug every time threads.
Instead, while I’m a big fan of the ubiquitous old 45 ACP, it is a thread in which I will state that I believe the only effective shot is the well-placed shot. Period.
What is the absolute best way to ensure your attacker goes down? Shot the bastard dead center his/her mouth perpendicular to the plane of the face.
Why? you’ll strike the spinal cord at the base of the brain.
Not that good of a shot even when NOT UNDER PRESSURE?
Go practice Dude.